EH 298. Environmental Epigenetics

Semester: 

Spring
  • Professor: Bernardo Lemos
  • Term: Spring
  • Days: T, Th
  • Time: 2:00-3:30
  • School: Harvard T.H. Chan School of Public Health
  • Course ID: 190216

Epigenetics is a fast changing field, with increasing applicability in toxicology, epidemiology, population, and environmental studies. Epigenetic changes are reversible, responsive to environmental influences, and can have downstream effects as profound as those exerted by DNA mutations. The course will focus on epigenetic mechanisms leading to alterations in chromatin structure that can stably and heritably influence gene expression and methods to measure epigenetic attributes (DNA methylation, histone modifications, small non-coding RNAs, etc). Basic, toxicological, and epidemiology studies will be discussed to introduce the students to epigenetic changes in prenatial/early and adult life, and examine the impact of pollutants, and diet. The course will enable students to understand epigenetics and apply it to problems as varied as those pertaining to cardiovascular and respiratory disease, aging, reproductive health, inflammation/immunity, and cancer.

Note: This course has priority enrollment. Cross-Registrants and Non-Degree Students will be enrolled on a space available basis after the enrollment deadline for the course.

Requirement: Students outside of HSPH must request instructor permission to enroll in this course.